Allopurinol 100mg
Class: Xanthine oxidase inhibitor (uric acid-lowering agent)
Manufacturer:
Dosage Form: Tablet
Similar Brands:
Uses:
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Gout (prevention of acute attacks)
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Hyperuricemia (e.g., due to chemotherapy)
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Uric acid kidney stones
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Tumor lysis syndrome
Dosage:
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Adults:
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Start with 100 mg once daily
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Usual maintenance: 200–600 mg/day in divided doses
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Max: 800 mg/day
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Children (for malignancy-related hyperuricemia):
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10 mg/kg/day in 3 divided doses
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Renal impairment: Dose adjustment required
Side Effects:
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Common: Rash, GI upset (nausea, diarrhea)
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Serious: Stevens-Johnson syndrome, hepatotoxicity, bone marrow suppression, hypersensitivity syndrome
Warnings & Precautions:
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Discontinue immediately if rash appears
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Use with caution in renal or hepatic impairment
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Ensure good hydration to prevent kidney stones
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Start colchicine or NSAID during initiation to prevent acute gout attacks
Pregnancy & Lactation:
Pregnancy: Use only if clearly needed (limited data)
Lactation: Use with caution; small amounts excreted in breast milk
Drug Interactions:
Azathioprine / Mercaptopurine: Reduce dose to 25%
Thiazide diuretics: Increased risk of hypersensitivity
Ampicillin/Amoxicillin: Increased risk of skin rash
Warfarin: Enhanced anticoagulant effect
Contraindications:
Hypersensitivity to allopurinol
Acute gout attack (should not be started during an attack)
Price: Ksh 450
Notes:
Pack Size: 30s