trypsin-chymotrypsin
Class: Systemic proteolytic enzyme preparation
Manufacturer: Global Napi Pharmaceuticals (GNP)
Dosage Form: Enteric-coated film-coated tablets
Similar Brands:
Uses:
Adjunctive treatment to reduce inflammation, swelling (edema), pain, and exudate in conditions such as:
- Trauma/injuries (e.g., bruises, sprains, fractures).
- Post-surgical or post-traumatic edema and inflammation.
- Inflammatory conditions (e.g., related to dental procedures, soft tissue injuries).
- Supportive in resolving hematomas, promoting wound healing, and enhancing penetration of antibiotics in infected/inflamed areas.
Not a primary treatment—often used alongside other therapies (e.g., painkillers, antibiotics).
Dosage:
Take on an empty stomach (e.g., 30 minutes to 1 hour before meals or 2 hours after) for optimal absorption.
Typical adult dose: 1–2 tablets 3–4 times daily (e.g., 2 tablets before each of 3 meals and 2 before bedtime, or 1–2 tablets 3 times daily).
Duration: Usually short-term (e.g., 5–10 days or until symptoms improve); follow doctor’s advice.
Adjust or avoid in severe renal/hepatic impairment—consult provider. No standard pediatric dosing; not typically recommended for children without medical supervision.
Typical adult dose: 1–2 tablets 3–4 times daily (e.g., 2 tablets before each of 3 meals and 2 before bedtime, or 1–2 tablets 3 times daily).
Duration: Usually short-term (e.g., 5–10 days or until symptoms improve); follow doctor’s advice.
Adjust or avoid in severe renal/hepatic impairment—consult provider. No standard pediatric dosing; not typically recommended for children without medical supervision.
Side Effects:
Common (mild, often gastrointestinal): Stomach upset, nausea, diarrhea, abdominal pain, bloating, indigestion.
Less common/rare: Skin rash/itching, drowsiness, headache, dizziness, allergic reactions (e.g., shortness of breath, swelling).
Serious (very rare): Severe allergic/hypersensitivity reactions (e.g., anaphylaxis—seek immediate care); potential for increased bleeding risk if combined with anticoagulants.
Less common/rare: Skin rash/itching, drowsiness, headache, dizziness, allergic reactions (e.g., shortness of breath, swelling).
Serious (very rare): Severe allergic/hypersensitivity reactions (e.g., anaphylaxis—seek immediate care); potential for increased bleeding risk if combined with anticoagulants.
Warnings & Precautions:
Take on empty stomach to avoid inactivation by gastric acid.
Use caution in patients with bleeding disorders, recent surgery, or those on anticoagulants/antiplatelets (may enhance fibrinolytic effects).
Stop at least 2 weeks before elective surgery due to potential interference with clotting.
Monitor for allergic signs—discontinue if rash, breathing difficulty, or swelling occurs.
Not for self-treatment of severe infections or acute conditions—requires medical oversight.
Enteric coating helps reduce GI irritation but may still cause upset in sensitive individuals.
Use caution in patients with bleeding disorders, recent surgery, or those on anticoagulants/antiplatelets (may enhance fibrinolytic effects).
Stop at least 2 weeks before elective surgery due to potential interference with clotting.
Monitor for allergic signs—discontinue if rash, breathing difficulty, or swelling occurs.
Not for self-treatment of severe infections or acute conditions—requires medical oversight.
Enteric coating helps reduce GI irritation but may still cause upset in sensitive individuals.
Pregnancy & Lactation:
Pregnancy: Limited data; animal studies on proteolytic enzymes show no major risks, but use only if clearly needed and under medical supervision (potential unknown effects on clotting/healing).
Lactation: Limited data; enzymes may pass minimally into breast milk—generally considered low risk but consult provider; weigh benefits vs. potential infant GI effects.
Lactation: Limited data; enzymes may pass minimally into breast milk—generally considered low risk but consult provider; weigh benefits vs. potential infant GI effects.
Drug Interactions:
Anticoagulants (e.g., warfarin, heparin) or antiplatelets: May increase bleeding risk—monitor closely.
Other fibrinolytic agents: Additive effects.
Minimal CYP450 interactions, but avoid combining with strong GI irritants if sensitive.
Other fibrinolytic agents: Additive effects.
Minimal CYP450 interactions, but avoid combining with strong GI irritants if sensitive.
Contraindications:
Known hypersensitivity to trypsin, chymotrypsin, or any component (including pork-derived enzymes, as trypsin/chymotrypsin are often porcine).
Active bleeding disorders or conditions with high bleeding risk (e.g., hemophilia).
Severe hepatic/renal impairment without adjustment.
Active bleeding disorders or conditions with high bleeding risk (e.g., hemophilia).
Severe hepatic/renal impairment without adjustment.
Price: Ksh 1197/-
Notes:
Pack Size: 30s