Class: Angiotensin II receptor blocker (ARB) + Thiazide diuretic Antihypertensive combination

Manufacturer: Square Pharmaceuticals Limited Bangladesh

Dosage Form: Tablet

Similar Brands:

Uses:

• Treatment of hypertension

• Reduction of stroke risk in hypertensive patients with left ventricular hypertrophy

• Patients inadequately controlled with monotherapy

Dosage:

Hypertension

• Usual starting dose: 1 tablet once daily
• Maximum:
  • 2 tablets 50/12.5 daily OR
  • 1 tablet 100/25 daily
• Full effect after ~3 weeks

Severe hypertension

• Start 50/12.5 once daily
• May increase after 2–4 weeks if needed

Renal impairment

• Use if creatinine clearance >30 mL/min
• Not recommended in severe impairment

Hepatic impairment

• Not recommended for dose titration

Can be taken with or without food.

Side Effects:

Common:

• Dizziness

• Edema

• Palpitations

• Abdominal pain

• Back pain

• Cough

• Sinusitis

• Rash

• Upper respiratory infections

Warnings & Precautions:

• Monitor electrolytes regularly

• Risk of fluid or electrolyte imbalance

• May precipitate gout

• May affect blood glucose control

• Monitor renal function when combined with NSAIDs

Pregnancy & Lactation:

• Pregnancy category D (avoid use)

• Present in breast milk; discontinue drug or breastfeeding

Drug Interactions:

• Potassium-sparing diuretics or supplements → hyperkalemia risk

• Lithium → increased lithium levels

• NSAIDs → reduced antihypertensive effect, renal risk

• Other antihypertensives → additive effect

• Alcohol, barbiturates → orthostatic hypotension

Contraindications:

• Hypersensitivity to components

• Anuria

• Sulfonamide hypersensitivity

• Concomitant use with aliskiren in diabetic patients

Price: Ksh 213/-

Notes:

Blister packs of tablets 30s