Celecoxib 200 mg + Paracetamol 325 mg + Chlorzoxazone 250 mg
Class: COX-2 selective NSAID + analgesic + central muscle relaxant combo
Manufacturer: Distributed by Krishna Chemist
Dosage Form: Tablet
Similar Brands:
Uses:
Short-term symptomatic relief of painful musculoskeletal conditions involving muscle spasm, inflammation, and pain, including:
- Acute muscle strains/sprains, back pain, neck pain, or spasms.
- Musculoskeletal disorders (e.g., lumbago, torticollis, fibromyalgia-like symptoms).
- Inflammatory conditions with muscle involvement (e.g., arthritis flares, post-injury pain).
- Adjunctive in pre/post-operative pain or trauma-related discomfort (not primary treatment).
Provides triple action: anti-inflammatory (celecoxib), pain relief (paracetamol), and muscle relaxation (chlorzoxazone). Not for long-term use (risk of side effects) or as sole therapy for chronic conditions—use with rest, physiotherapy, etc.
Dosage:
Oral, usually 1 tablet twice daily (or as directed by doctor; with food to minimize stomach upset).
Adults: 1 tablet every 12 hours (max 2 tablets/day; short-term, e.g., 5–10 days).
Elderly/renal/hepatic impairment: Lower dose or avoid (increased risk).
Children: Not recommended (limited data/safety not established).
Duration: Short-term only (doctor-supervised); do not exceed prescribed dose/course. Discontinue if no improvement after a few days.
Adults: 1 tablet every 12 hours (max 2 tablets/day; short-term, e.g., 5–10 days).
Elderly/renal/hepatic impairment: Lower dose or avoid (increased risk).
Children: Not recommended (limited data/safety not established).
Duration: Short-term only (doctor-supervised); do not exceed prescribed dose/course. Discontinue if no improvement after a few days.
Side Effects:
Common (mild/transient): Stomach upset/pain, nausea, heartburn, diarrhea/constipation, headache, dizziness, drowsiness (from chlorzoxazone), rash.
Less common: Edema/swelling, hypertension (celecoxib), fatigue, dry mouth, urine discoloration (harmless from chlorzoxazone).
Serious (rare, seek immediate care): GI bleeding/ulcers/perforation (black stools, vomiting blood—higher with celecoxib), severe allergic reactions (rash, swelling, breathing difficulty), liver damage (jaundice, dark urine), kidney issues, cardiovascular events (heart attack/stroke risk with prolonged NSAID use), severe muscle weakness or hepatotoxicity.
Less common: Edema/swelling, hypertension (celecoxib), fatigue, dry mouth, urine discoloration (harmless from chlorzoxazone).
Serious (rare, seek immediate care): GI bleeding/ulcers/perforation (black stools, vomiting blood—higher with celecoxib), severe allergic reactions (rash, swelling, breathing difficulty), liver damage (jaundice, dark urine), kidney issues, cardiovascular events (heart attack/stroke risk with prolonged NSAID use), severe muscle weakness or hepatotoxicity.
Warnings & Precautions:
Take with food; monitor for GI bleeding (higher risk in elderly, history of ulcers, or with other NSAIDs/alcohol).
Cardiovascular risk: Celecoxib may increase heart attack/stroke risk (use lowest dose/shortest duration).
Liver/kidney monitoring: Avoid in severe impairment or active liver disease.
Not for asthma exacerbated by NSAIDs (aspirin triad risk).
Drowsiness: Avoid driving/machinery if affected.
Not for long-term use without doctor (risk of rebound or complications).
Stop if rash, severe pain, or worsening symptoms occur
Cardiovascular risk: Celecoxib may increase heart attack/stroke risk (use lowest dose/shortest duration).
Liver/kidney monitoring: Avoid in severe impairment or active liver disease.
Not for asthma exacerbated by NSAIDs (aspirin triad risk).
Drowsiness: Avoid driving/machinery if affected.
Not for long-term use without doctor (risk of rebound or complications).
Stop if rash, severe pain, or worsening symptoms occur
Pregnancy & Lactation:
Pregnancy: Avoid (especially third trimester—celecoxib risks fetal ductus arteriosus closure; paracetamol safer short-term but consult doctor).
Lactation: Not recommended (components pass into milk—risk to infant); consult provider.
Lactation: Not recommended (components pass into milk—risk to infant); consult provider.
Drug Interactions:
Other NSAIDs/aspirin: Increased GI/bleeding risk.
Anticoagulants (warfarin): Enhanced bleeding.
ACE inhibitors/diuretics: Reduced antihypertensive effect + renal risk.
Lithium/methotrexate: Increased toxicity.
Alcohol: Enhanced GI irritation/sedation.
Anticoagulants (warfarin): Enhanced bleeding.
ACE inhibitors/diuretics: Reduced antihypertensive effect + renal risk.
Lithium/methotrexate: Increased toxicity.
Alcohol: Enhanced GI irritation/sedation.
Contraindications:
Hypersensitivity to celecoxib, paracetamol, chlorzoxazone, sulfonamides (celecoxib cross-reactivity), or excipients.
Active peptic ulcer/GI bleeding.
Severe liver/kidney/heart failure.
Third-trimester pregnancy.
History of asthma/urticaria/angioedema after NSAIDs.
Active peptic ulcer/GI bleeding.
Severe liver/kidney/heart failure.
Third-trimester pregnancy.
History of asthma/urticaria/angioedema after NSAIDs.
Price: Ksh 1200/-
Notes:
Pack Size: 10s