Triokit

Class: Antibiotics

Manufacturer: Zest Pharma 275, Sector “F” Sanwer road Indore – (INDIA)

Dosage Form: Tablets

Similar Brands:

Uses:

Triokit is indicated for the syndromic management of vaginal discharge. Clinical manifestations range from asymptomatic carriage to severe inflammatory signs and symptoms. Approximately one third of asymptomatic female carriers become symptomatic within 6 months. Typical symptoms include vaginal or introital itch plus discharge. The classical clinical feature-bright red vaginal mucosa and a yellow of green frothy, malodorous discharge are often evident but some cases merely present as a mildly inflamed vagina of non-specific appearance, or even without any abnormalities.

Dosage:

Azithromycin 1g tablet as a single oral dose under supervision, fluconazole 150mg orally as a single dose. Secnidazole 2g single dose  (administration of 2 secnidazole 1g tablets).

Administration

The absorption of azithromycin is hampered by presence of food in the stomach. Hence azithromycin to be administered 1 hour before meals. Fluconazole administration is not hampered by presence of food , on tablet of fluconazole to be administered after lunch. 2 tablets of secnidazole to be administered after the food preferably at bed time. This shall avoid the unwanted G.I. disturbance.

Directions for use

Take azithromycin 1 tablet on empty stomach, 1 hour before lunch

Fluconazole 1 tablet to be taken after lunch

Secnidazole 2 tablets to be taken as a single dose after dinner at bed time.

Triokit is meant for one day’s treatment as single dose of azithromycin, fluconazole and secnidazole

Side Effects:

Common side effects of the combination of Azithromycin, Fluconazole, and Secnidazole may include altered taste, vomiting, headache, dizziness, abdominal pain, nausea, indigestion, diarrhea, and reduced appetite.

Warnings & Precautions:

Take as directed by your physician

Pregnancy & Lactation:

Not recommended

Drug Interactions:

Not indicated in the insert

Contraindications:

Triokit contains three chemotherapeutics azithromycin, fluconazole and secnidazole. These 3 drugs do not cause drug interactions when given together on the same day concomitantly. However, like any therapeutic agent azithromycin, fluconazole and secnidazole have known contraindications, which must be known before triokit is prescribed to a patient.

Azithromycin contraindications

Azithromycin is contraindicated in patients with known hypersensitivity to azithromycin, erythromycin, or any macrolide antibiotic.

Fluconazole contraindication

Hypersensitivity to fluconazole, or to any excipients in the product. There is no information regarding cross hypersensitivity between fluconazole and other azole antifungal agents, use with caution in patients with hypersensitivity to other azoles.

Secnisazole contraindications

As in case of other nitroimidazole derivative, the drug should not be administered during the first trimester of pregnancy, or lactation, or in individual hypersensitive to nitroimidazole derivatives.

Price: Ksh 810

Notes:

Description

Triokit containing: azithromycin, fluconazole, and secnidazole is a kit of 3 drugs to treat vaginal discharge. The treatment is recommended on the principle of “syndromic management of sexually transmitted diseases”. The syndromic approach has identified 7 common presenting symptoms. Vaginal discharge is one of the commonest symptoms in women.

Microbiology

Causative organism: the three most common cause of vaginitis are;

Bacteria – n. gonorrhea, c.trachomatis, gardnerella vaginalis

Fungi – candida albicans (monilla)

Parasite – trichomonas vaginalis

Antiifective action

Based on causative infective organism of vaginal discharge the triokit contains: antibacterial- azithromycin, antifungal-fluconazol, antitrichomonal  – secnidazole. Azithromycin eradicates n. gonorrhea and c. trachomatis, fluconazole eradicates candida albicans. Secnidazole is effective against trichomonas vaginalis and bacteria causing bacterial vaginosis (gardnerella vaginalis and anaerobes)