Aminosidine U.S.P (as sulphate)
Class: Aminoglycoside antibiotic
Manufacturer: Universal Corporation Ltd, Club Road, Plot No. 13777, Kenya.
Dosage Form: Tablet & Syrup
Similar Brands:
Uses:
Aminosidine (paramomycin) is an aminoglycoside antibiotic that has been administered by mouth as a sulphate in the treatment of intestinal protozoal infection including amoebiasis, cryptosporidiosis and giardiasis. It has also been tried parenterally for visceral and topically for cutaneous leishmaniasis. Aminosidine may also be used for the treatment of tapeworm infection, but it is not the treatment of choice. Similarly to neomycin, aminosidine has been used in the suppression of intestinal flora both preoperatively and in the management of hepatic encephalopathy
Dosage:
For amoebiasis, Lambliasis, cryptosporidiosis and trichomoniasis:
Adult: 500mg twice per day for six (6) days.
Children: 15mg/kg/day for 6 days
For prophylactic sterilization in gastrointestinal surgery:
Adult: 2gm daily for three days
Children: 50mg/kg/day for three days
In taeniasis and other tapeworm infections: a dose of 4gm is given by mouth as a single dose or in divided doses over the course of one hour.
For hepatic encephalopathy: 4gm is given by mouth in divided doses at regular intervals for 5 to 6 days.
Side Effects:
Includes nausea, vomiting and diarrhea. Prolonged oral therapy may cause a malabsorption syndrome with steatorrhea and diarrhea which can be very severe; supra-infection may occur, especially with prolonged oral treatment.
Warnings & Precautions:
Aminosidine is contraindicated for intestinal disinfection when an obstruction is present an in patients with a known history of allergy to aminoglycosides. It should be used with great care in patients with kidney or liver disease on neuromascular disorders and those with impaired hearing.
Pregnancy & Lactation:
Aminosidine is generally avoided during pregnancy due to potential fetal ototoxicity, but oral use may be considered if clearly needed, as it is poorly absorbed systemically.
Drug Interactions:
Absorption following oral administration may be sufficient to produce interactions with other drugs administered systemically. Aminosidine taken by mouth may impair the absorption of other drugs including phenoxymethylpenicillin, digoxin, methotrexate, and some vitamins, the efficacy of oral contraceptives might be reduced. Aminosidine may enhance the effects of acarbose
Contraindications:
Aminosidine is contraindicated in individuals with known hypersensitivity to aminosidine or other aminoglycosides, those with intestinal obstruction (when used orally), and patients with severe renal impairment due to the risk of drug accumulation and toxicity. It should also be avoided in individuals with pre-existing hearing loss because of its ototoxic potential. Although the oral form is poorly absorbed and may be considered in certain cases, the use of injectable aminosidine is contraindicated during pregnancy due to the risk of fetal harm, particularly ototoxicity.
Price: Ksh 350
Notes:
Pack Size: Syrup 60ml and 100ml in (amber coloured glass/PET bottles), Tablets blister pack of 12s and 24s in unit boxes
Unibrol syrup is Ksh 350/-
Unibrol tablet is Ksh 1080/-
Composition
Unibrol syrup: Each 5ml contains 125mg aminosidine U.S.P(as sulphate)
Unibrol Tablet: Each tablet contains 250mg aminosidine U.S.P(as sulphate)
Clinical pharmacology
Aminosidine is active against various protozoa including: Leishmaniaspp, Entamoeba histolytica, and cryptosporidium spp. In addition, it has an antibacterial spectrum similar to that of neomycin. It is active against many strains of gram-negative bacteria including species of Brucella, calymmatobacterium, campylobacter, citrobacter, Escherichia, Enterobacter, klebsiella, proteus, serratia vibrio and Yersinia. Aminosidine has been reported to be active against mycobacterium tuberculosis but lacks activity against pseudomonas aeruginosa.
Ref: Z/PLLE00108/X/000