ASCARD-75

Description

Composition

Acetylsalicylic acid B.P.

What is Ascard-75?

ASCARD-75 is enteric coated Acetylsalicylic Acid (Asprin) available in tablet form in 75mg.

The enteric coated Ascard-75 is designed to resist disintegration in the stomach, but to dissolve in a better neutral-to-alkaline environment of the duodenum. Special enteric coating helps to protect the stomach from injury which may result from ingestion of pain, buffered or highly aspirin, and the patients still gets the same serum salicylate levels and anti-platelet activity as with other for of aspirin.

Ascard-75 is also indicated for

Conditions requiring chronic or long-term aspirin therapy for pain and or inflammation, e.g. rheumatoid arthritis, juvenile arthritis, systemic lupus, erythematous, osteoarthritis (degenerative joint disease), ankylosing spondylitis, psoriatic arthritis, Reiter’s syndrome and fibrositis.

ASCARD-75 is also used for the relief of pain and inflammation in rheumatic fever.

Dosage and Administration

Angina pectoris/Myocardial infarction

The recommended dosage indicated for anti-platelet function, 75mg daily or as directed by the physician.

•  Study in 333 USA physicians with “unstable angina” indicated that low dose aspirin reduces the risk for 1st myocardial infarction. “Ref: Manson JE, et al. Aspirin in primary prevention of angina pectoris in randomized trial of USA physicians 1990”
• Patients with silent Ischemia may benefit from low dose aspirin. Aspirin can be used as initial management to stop thrombosis progression and increase coronary blood flow. “Ref: Redker PM et al, low dose aspirin therapy for chronic stable angina: a randomized, placebo control clinical trial”
• Single doses of 40 to 80mg and 50mg respectively are capable of inhibiting platelet aggregation without having a significant or long lasting effect on vascular prostacyclin. “Robert et al (lancet 1986, 1, 1153)

For transient ischemic attacks, for analgesic or anti-inflammatory indications;

The dosage can be increased or modified according to the clinical situation of the individual patient under a physician’s directions.

WARNING

Children and teenagers should not use this medicine for chicken pox or flu symptoms, before a doctor is consulted about Reye’s syndrome, a rare but serious illness. If pain persists for more than 10 days, or if redness is present, or in arthritic or rheumatic conditions affecting children under 12 years consult a physician immediately. Discontinue use if dizziness, ringing ears or impaired hearing occurs. If you experience persistent or unexplained stomach upset, consult your physician. As with any medicine, in case of pregnancy and lactation the drug should be taken under medical advice.

The drug should not be used during the last 3 months of pregnancy unless specially directed by the doctor as it may cause problems in the fetus or complications during pregnancy.

ADVERSE REACTION

Gastrointestinal Reactions: Stomach pain (14.5%, 4.4%); heartburn (11.9%); nausea or vomiting (7.6%, 2.1%); hospitalization for gastrointestinal disorder patients had increased rates of gross gastrointestinal bleeding. In the AMIS and other trials, plain aspirin-treated patients had increased rates of gross gastrointestinal bleeding. Symptoms and sings of gastrointestinal irritation were not significantly increased in subjects treated for unstable angina with buffered aspirin in solution.