Clozole B Cream 15gm

Description

Composition

Each gram contains: Clotrimazole BP 10.0mg, Betamethasone Dipropionate equivalent to betamethasone BP 0.5mg.

• Clotrimazole  is an antifungal agent that treats infections like athlete’s foot, ringworm, and yeast infections.
• Beclomethasone is a corticosteroid that helps reduce inflammation, redness, itching, and swelling associated with various skin conditions.

Indications

Candida sp, candidiasis, epidermopjyton floccusum, microsporum cains, tinea crusis, trichophyton mentragrophytes, tricophyton rebrum, candida albicans, tinea corporis, tinea pedis.

Dosage

For treatment of tinea corpis, tinea crusis, of tinea pedis (Epidermophyton floccosum, Microsporum canis; Trichophyton rubrum)

Topical dosage: Adults and children > 12 years of age: Apply sparingly to affected skin and surrounding areas twice daily, morning and evening.

For secondary treatment of candidiasis with inflammation due to susceptible strains of candida sp. including candida albicans:

Topical dosage: Adults and children >12 years of age: Apply sparingly to the affected skin area and surrounding areas twice daily.

Administration Guidelines

For the topical dermatologic use only. Not for ophthalmic, oral or intravaginal use.

1. Wash hands before and after application.
2. Use gloves if required.
3. Apply sparingly in a thin film and rub gently into affected area(s) if clean, dry skin. Restrict application to the affected areas and try to avoid normal surrounding skin.
4. Patients who fail to respond to topical treatment after 1-4 weeks should be re-evaluated.
5. The amount cream needed to cover a certain skin area can be calculated. A 1gm application of the cream covers 100cm² of the skin. The entire skin surface if the average size adult will be covered by 30gm of topical cream.

Topical preparations containing steroids generally should not be used with occlusive dressings, instruct patients not to bandage, cover, or wrap area in a way that may be occlusive, unless directed by the prescriber.

Contraindications

• Azole hypersensitivity
• Children
• Infants
• Skin abrasion
• Breast feeding
• Elderly
• Peripheral vascular disease
• Skin atrophy

Drug Interaction

Nystatin: Imidazole type antifungal agents such as clotrimazole inhibits the synthesis of fungal steror ergosterol while the therapeutic actions of polyene antifungals such as amphotericin B and nystatin result from the binding to the ergosterol. There is the potential that clotrimazole may inhibit the antifungal effects of ampotericin B or nystatin, an interaction between systemic ampotericin B and topical clotrimazole is unlikely due to the limited systemic absorption of clotrimazole.

Adverse Reactions

• Acneiform rash
• Cushings syndrome
• Erythena
• Hyperglycemia
• Hyperthalamic pituitary adrenal (H.P.A) suppression
• Maculapapular rash
• Paresthesias
• Skin atrophy
• Striae
• Xerosis
• Contact dermatitis
• Edema
• Foilculitis
• Infenction hyperglycemia
• Miliaria
• Pruritus
• Skin hypopigmentation
• Vesicular rash

Clozole B cream 15g is manufactured by Shalina Healthcare Kenya Limited